反应详情

A solution of tert-butyl 8-(4-chlorophenyl)-8-hydroxy-5-azaspiro[2.5]octane-5-carboxylate (1.81 g, 5.36 mmol) in dioxane (2 mL) was treated with 4.0 M HCl in dioxane (7 mL, 28.0 mmol), and the reaction was stirred for 30 minutes at room temperature. The mixture was concentrated in-vacuo then concentrated 2× from methylene chloride to remove residual HCl. The residue was dissolved in water and washed 2× with diethyl ether. The aqueous phase was treated with sodium bicarbonate until the mixture was basic, then washed 2× with 10 mL diethyl ether. The aqueous phase was treated with solid sodium hydroxide until the pH was >13, and the mixture was extracted 5× with ethyl acetate. The combined ethyl acetate extracts were dried over sodium sulfate and concentrated in vacuo to yield (±)-8-(4-chlorophenyl)-5-azaspiro[2.5]octan-8-ol as a colorless powder (1.1 g, 87% yield). MS (ESI+)=238.1, (M+H)+. The isomers were separated via chiral super critical fluid chromatography to yield 463 mg of isomer A and 522 mg of isomer B.

1. concentrationThe mixture was concentrated in-vacuo
2. concentrationthen concentrated 2× from methylene chloride
3. customto remove residual HCl
4. dissolutionThe residue was dissolved in water
5. washwashed 2× with diethyl ether
6. additionThe aqueous phase was treated with sodium bicarbonate until the mixture
7. washwashed 2× with 10 mL diethyl ether
8. additionThe aqueous phase was treated with solid sodium hydroxide until the pH was >13
9. extractionthe mixture was extracted 5× with ethyl acetate
10. dry with materialThe combined ethyl acetate extracts were dried over sodium sulfate
11. concentrationconcentrated in vacuo