反应详情

(S)-4-(4-chlorophenyl)-3,3-dimethylpiperidin-4-ol (100 mg, 0.42 mmol), (R)-2-(tert-butoxycarbonylamino)butanoic acid (102 mg, 0.50 mmol), HOBT (68 mg, 0.5 mmol), EDC (155 mg, 1 mmol), DIPEA (129 mg, 1 mmol), and chlororform (2 mL) was stirred overnight at rt. The reaction mixture was then partitioned between methylene chloride and saturated sodium bicarbonate solution, the layers were separated and the organic extracts were dried over magnesium sulfate, filtered, and concentrated to yield the product, which was used in next step without further purification.

1. customThe reaction mixture was then partitioned between methylene chloride and saturated sodium bicarbonate solution
2. customthe layers were separated
3. dry with materialthe organic extracts were dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customto yield the product, which
7. customwas used in next step without further purification