4-Chloropyridine-2-carboxamide → 4-(4-Amino-2,6-difluorophenoxy)picolinamide

HRID 101622Notes

Reaction equation

HRID 101622 reaction equation
[Cl:1][c:2]1[cH:3][c:4]([C:8](=[O:9])[NH2:10])[n:5][cH:6][cH:7]1.[F:11][c:12]1[cH:13][c:14]([NH:15][C:16]([c:17]2[c:18](=[O:19])[n:20](-[c:21]3[cH:22][cH:23][cH:24][cH:25][cH:26]3)[cH:27][cH:28][cH:29]2)=[O:30])[cH:31][cH:32][c:33]1[O:34][c:35]1[cH:36][cH:37][n:38][cH:39][c:40]1-[c:41]1[cH:42][cH:43][c:44]([CH2:45][CH2:46][OH:47])[cH:48][cH:49]1.[NH2:50][c:51]1[cH:52][c:53]([F:59])[c:54]([OH:58])[c:55]([F:57])[cH:56]1>>[c:2]1([O:58][c:54]2[c:53]([F:59])[cH:52][c:51]([NH2:50])[cH:56][c:55]2[F:57])[cH:3][c:4]([C:8](=[O:9])[NH2:10])[n:5][cH:6][cH:7]1

Participants

4

Reactant 3

HCID 3035434-Chloropyridine-2-carboxamideHCID 27787644-Amino-2,6-difluorophenolHCID 11649323N-(3-Fluoro-4-(3-(4-(2-hydroxyethyl)phenyl)pyridin-4-yloxy)phenyl)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide

Product 1

HCID 598528534-(4-Amino-2,6-difluorophenoxy)picolinamide

Sources & evidence

ORD record
ord-0bee5c72af5541448556cf327c99e7b4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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