Methyl iodide → HCID 18406201, compound

Participants

Reaction Steps

6.2 g of methyl iodide were added dropwise at 80° C. to a solution of 12.6 g of 3-hydroxynaphthalene-2-carboxylic acid (3-morpholin-4-ylpropyl)amide (RN 10155-47-2) in 60 ml of chlorobenzene. After refluxing for 4 hours, the suspension was cooled, filtered on a sinter funnel and spin-filtered. The white precipitate was washed with 20 ml of chlorobenzene and then with 20 ml of petroleum ether. The precipitate was then dried under vacuum. 12.5 g of a white solid of 4-{3-[(3-hydroxynaphthalene-2-carbonyl)amino]propyl}-4-methylmorpholin-4-ium iodide were obtained in a yield of 69%, melting at a temperature above 260° C. (Kofler) and the elemental analysis of which, calculated for C19H25N2O3.I, was:

Provenance & Evidence