Morpholine → HCID 18406217, compound

HRID 1016224Notes

Reaction equation

HRID 1016224 reaction equation
[C:1]([C:5]1[CH:10]=[C:9]([CH:11](O[Si](C)(C)C)[CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:8]=[C:7]([C:25]([CH3:28])([CH3:27])[CH3:26])[C:6]=1[OH:29])([CH3:4])([CH3:3])[CH3:2].[NH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>CCCCCC>[C:25]([C:7]1[CH:8]=[C:9]([CH:11]([N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)[CH2:12][CH2:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:10]=[C:5]([C:1]([CH3:2])([CH3:3])[CH3:4])[C:6]=1[OH:29])([CH3:26])([CH3:27])[CH3:28]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 18406232HCID 18406232, compound

Product 1

HCID 18406217HCID 18406217, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

To a nitrogen-purged, 250 mL, three-neck, round-bottom flask were added the 148.9 grams of the 2,6-di-t-butyl-4-(1-trimethylsilyloxy-3-phenylpropyl)phenol produced in step (B) of this example, 67 grams of hexane, and 45.8 grams (0.53 mole) of morpholine. The mixture was stirred overnight at ambient temperature. After this time, the solvent was removed and the solids recrystallized from a solution of 5 percent toluene in hexane to give pure 2,6-di-t-butyl-4-(1-morpholino-3-phenylpropyl)phenol as a white crystalline solid.

Workup

  1. customTo a nitrogen-purged
  2. customAfter this time, the solvent was removed
  3. customthe solids recrystallized from a solution of 5 percent toluene in hexane

Sources & evidence

ORD record
ord-2ea87b618e7a4c82ba09d5069888b499
Source dataset
uspto-grants-2002_11
Patent number
US06475347B1

Reaction notes

Loading…