関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | alpha-D-galactosyl fluoride | HCID 10921145 | — |
| 触媒 | Silver(II) oxide | HCID 92152 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2,3,4,6-Tetra-O-benzyl-alpha-D-galactopyranosyl Fluoride | HCID 9959029 | — |
反応手順
α-D-galactopyranosyl fluoride (2.30 g, 12.62 mmol) was dissolved in dry DMF (40 ml) and, at −20° C., benzyl bromide (12.95 g, 75.72 mmol) and silver oxide (10 g) were added. The reaction mixture was stirred at −20° C. for 5 h and then at room temperature for 24 h. The salts were then filtered off and the filtrate was evaporated in vacuo. The residue was purified by column chromatography on silica gel (350 g) with 15:1 petroleum ether/ethyl acetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06475486B1 |
|---|
| 出典データセット | uspto-grants-2002_11 |
|---|
| ORD ID | ord-cffac80fabff41b9adf82ecb8d529601 |
|---|
| 出典メモ | uspto-grants-2002_11 |
|---|
