Methanol → HCID 10582652, compound

Participants

Reaction Steps

Compound 33 was prepared by esterification of crude 32 (436 mg) with MeOH as described for the preparation of 9. Purification of the residue by flash chromatography on a 3×21 cm column of silica gel using hexanes/EtOAc (2:1) as eluent gave 268 mg (52%, three steps) 33 as a white solid. Data for 33: TLC, T-5, Rf0.76. 1H NMR (500 MHz, CDCl3) δ 0.81 (s, 3H, H-1 8), 2.84 (m, 2H, H-6), 3.31 (d, 1H, J=7.3 Hz, H-17α), 3.69 (s, 3H, OCH3), 5.04 (s, 2H, benzylic), 6.72 (d, 1H, J=2.8 Hz, H-4), 6.79 (dd, 1H, J=8.6, 2.8 Hz, H-2), 7.21 (d, 1H, J=8.6 Hz, H-1), 7.31-7.44 (m, 5H, Ar—H); HRMS (ES) calcd for C29H36O4Na (M+Na+) m/e 471.2511, found m/e 471.2513.

Provenance & Evidence