HCID 86758589, compound → HCID 86758587, compound

Participants

Reaction Steps

Compound 21 (38 mg) was dissolved in 2 mL of 10 M methyl amine in methanol and stirred in a sealed vial for 50 d. The reaction mixture was then concentrated under reduced pressure. Flash chromatography (SiO2, 5:2:0.25 CHCl3/MeOH/H2O containing 0.5% conc. NH4OH) gave the desired product (25 mg) was awhite solid. 1H NMR (D2O, 300 MHz) 7.588 (d, J=1.1 Hz, 1H), 6.081 (t, J=6.8 Hz, 1H), 4.275 (m, 1H), 3.995 (m, 1H), 3.896-3.746 (m, 2H), 3.403 (m, 1H), 2.570 (s, 3H), 2.320 (m, 2H), 1.753 (d, J=1.1 Hz, 3H), 1.504 (m, 1H), 1.352-1.225 (m, 2H), 0.693 (d, J=6.6 Hz, 6H); 31P NMR (D2O, 121 MHz) 6.359.

Provenance & Evidence