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HRID1016275

反应详情

EQUATION

反应方程式

HRID 1016275 的结构方程式

REACTANTS

反应物

3
结构：COC(=O)[C@H](N)Cc1ccccc1
HCID853474

(+)-Phenylalanine methyl ester

C10H13NO2

结构：CO.ClC(Cl)Cl.O
HCID21866399

未命名化合物

结构：CC[NH+](CC)CC.CC[NH+](CC)CC.Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](COP([O-])[O-])O2)c(=O)[nH]c1=O
HCID22892882

未命名化合物

PRODUCTS

生成物

1
结构：COc1cccc(C[C@@H](N)C(=O)OP(N)(=O)[O-])c1.Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O
HCID131723622

未命名化合物

收率 68%

PROCEDURE

实验过程

Compound 40 (340 mg, 0.785 mmol) and D-phenylalanine methyl ester (HCl salt, 339 mg, 1.57 mmol) were subjected to a procedure similar to that described in Example 6. Flash chromatography (SiO2, 5:2:0.25 CHCl3/MeOH/H2O containing 0.5% conc. NH4OH) gave the title compound (282 mg, 68%) as a white solid. 1H NMR (D2O, 300 MHz) 7.415 (s, 1H), 7.1580-6.998 (m, 5H), 5.995 (t, J=6.8 Hz, 1H), 4.118 (m, 1H), 3.808 (m, 1H), 3.738 (m, 1H), 3.661 (m, 1H), 3.467 (m, 1H), 3.403 (s, 3H), 2.754 (m, 2H), 2.212 (m, 2H), 1.679 (s, 3H); 31P NMR (D2O, 121 MHz) 6.204; HRMS (FAB) m/z calcd for C13H20N6O8P (M+H)+ 419.1080, found 419.1103.