3-Bromo-1-propanol → 10-bromo-5-(3-hydroxypropyloxy)-2-(3-pyridylmethyl)-3H-pyrido[3,2,1-kl]phenothiazin-3-one

HRID 1016307Notes

Reaction equation

HRID 1016307 reaction equation
[Br:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6]4=[C:7]([C:17](=[O:27])[C:18]([CH2:20][C:21]5[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=5)=[CH:19][N:5]4[C:4]=2[CH:3]=1)[CH:8]=[C:9]([OH:16])[CH:10]=3.Br[CH2:29][CH2:30][CH2:31][OH:32]>>[Br:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6]4=[C:7]([C:17](=[O:27])[C:18]([CH2:20][C:21]5[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=5)=[CH:19][N:5]4[C:4]=2[CH:3]=1)[CH:8]=[C:9]([O:16][CH2:29][CH2:30][CH2:31][OH:32])[CH:10]=3

Participants

3

Reactant 2

HCID 123083-Bromo-1-propanolHCID 1202110510-bromo-5-hydroxy-2-(3-pyridylmethyl)-3H-pyrido[3,2,1-kl]phenothiazin-3-one

Product 1

HCID 1202110610-bromo-5-(3-hydroxypropyloxy)-2-(3-pyridylmethyl)-3H-pyrido[3,2,1-kl]phenothiazin-3-oneYield 73%

Procedure

According to Example 34, the compound (300 mg) produced in Example 37 was reacted with 3-bromopropanol (78 μL) to obtain the title compound (210 mg; 73%).

Sources & evidence

ORD record
ord-8ca37a2382c84500a8d866e47bcd8f29
Source dataset
uspto-grants-2002_11
Patent number
US06476021B1

Reaction notes

Loading…