3,5-Dimethylpyridine → HCID 12021108, compound

HRID 1016309Notes

Reaction equation

HRID 1016309 reaction equation
[Br:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6]4=[C:7]([C:17](=[O:27])[C:18]([CH2:20][C:21]5[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=5)=[CH:19][N:5]4[C:4]=2[CH:3]=1)[CH:8]=[C:9]([OH:16])[CH:10]=3.Cl[CH2:29][C:30]1[CH:31]=[N:32][CH:33]=[C:34]([CH3:36])[CH:35]=1.CC1C=NC=C(C)C=1>>[Br:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6]4=[C:7]([C:17](=[O:27])[C:18]([CH2:20][C:21]5[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=5)=[CH:19][N:5]4[C:4]=2[CH:3]=1)[CH:8]=[C:9]([O:16][CH2:29][C:30]1[CH:31]=[N:32][CH:33]=[C:34]([CH3:36])[CH:35]=1)[CH:10]=3

Participants

4

Reactant 3

HCID 115653,5-DimethylpyridineHCID 119627823-(CHLOROMETHYL)-5-METHYLPYRIDINEHCID 1202110510-bromo-5-hydroxy-2-(3-pyridylmethyl)-3H-pyrido[3,2,1-kl]phenothiazin-3-one

Product 1

HCID 12021108HCID 12021108, compoundYield 10%

Procedure

According to Example 34, the compound (150 mg) produced in Example 37 was reacted with 3-chloromethyl-5-methylpyridine synthesized from 3,5-dimethylpyridine (500 mg) to obtain the title compound (180 mg; 10%).

Sources & evidence

ORD record
ord-0cf8adf304a04477a2c3f3240faebc3a
Source dataset
uspto-grants-2002_11
Patent number
US06476021B1

Reaction notes

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