Sodium Hydroxide → 10-bromo-5-(5-hydroxymethyl-3-pyridylmethyloxy)-2-(3-pyridylmethyl)-3H-pyrido[3,2,1-kl]phenothiazin-3-one

Participants

Reaction Steps

The compound (220 mg) obtained in Example 41 was suspended in methanol(10 mL) and to the suspension was added dropwise a solution of sodium hydroxide (90 mg) in water (1 mL). The mixture was stirred at room temperature overnight. After the end of reaction, the precipitate crystals were collected by filtration and washed with methanol and ether in turns to obtain the title compound (180 mg; 91%).

Provenance & Evidence