3-(Chloromethyl)pyridine hydrochloride → HCID 18406524, compound

HRID 1016319Notes

Reaction equation

HRID 1016319 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]3[CH:19]=[C:18]([CH2:20][C:21]4[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=4)[C:17](=[O:27])[C:8]4[CH:9]=[C:10]([OH:16])[CH:11]=[C:12]([S:13][C:14]=2[CH:15]=1)[C:7]3=4.Cl.Cl[CH2:30][C:31]1[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]3[CH:19]=[C:18]([CH2:20][C:21]4[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=4)[C:17](=[O:27])[C:8]4[CH:9]=[C:10]([O:16][CH2:30][C:31]5[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=5)[CH:11]=[C:12]([S:13][C:14]=2[CH:15]=1)[C:7]3=4

Participants

3

Reactant 2

HCID 233943-(Chloromethyl)pyridine hydrochlorideHCID 12021117HCID 12021117, compound

Product 1

HCID 18406524HCID 18406524, compoundYield 95.2%

Procedure

According to Example 34, the compound (120 mg) produced in Example 54 was reacted with 3-chloromethylpyridine hydrochloride (68 mg) to obtain the title compound (138 mg; 95%).

Sources & evidence

ORD record
ord-e970ca29b3c2447690fe410aa7560201
Source dataset
uspto-grants-2002_11
Patent number
US06476021B1

Reaction notes

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