3-(Chloromethyl)pyridine hydrochloride → HCID 18406511, compound

HRID 1016327Notes

Reaction equation

HRID 1016327 reaction equation
[CH2:1]([C:8]1[C:9](=[O:27])[C:10]2[CH:11]=[C:12]([OH:26])[CH:13]=[C:14]3[C:23]=2[N:22]([CH:24]=1)[C:21]1[CH:20]=[C:19]([Br:25])[CH:18]=[CH:17][C:16]=1[S:15]3)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.Cl[CH2:30][C:31]1[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=1>>[CH2:1]([C:8]1[C:9](=[O:27])[C:10]2[CH:11]=[C:12]([O:26][CH2:30][C:31]3[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=3)[CH:13]=[C:14]3[C:23]=2[N:22]([CH:24]=1)[C:21]1[CH:20]=[C:19]([Br:25])[CH:18]=[CH:17][C:16]=1[S:15]3)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 233943-(Chloromethyl)pyridine hydrochlorideHCID 18406569HCID 18406569, compound

Product 1

HCID 18406511HCID 18406511, compoundYield 62%

Procedure

According to Example 34, the compound (200 mg) produced in Example 70 was reacted with 3-chloromethylpyridine hydrochloride (145 mg) to obtain the title compound (149 mg; 62%).

Sources & evidence

ORD record
ord-0894d9add600460ba70edb63aa2ef947
Source dataset
uspto-grants-2002_11
Patent number
US06476021B1

Reaction notes

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