1-(2-Chloroethyl)piperidine → HCID 18406514, compound

HRID 1016328Notes

Reaction equation

HRID 1016328 reaction equation
[CH2:1]([C:8]1[C:9](=[O:27])[C:10]2[CH:11]=[C:12]([OH:26])[CH:13]=[C:14]3[C:23]=2[N:22]([CH:24]=1)[C:21]1[CH:20]=[C:19]([Br:25])[CH:18]=[CH:17][C:16]=1[S:15]3)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:29][CH2:30][N:31]1[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH2:1]([C:8]1[C:9](=[O:27])[C:10]2[CH:11]=[C:12]([O:26][CH2:29][CH2:30][N:31]3[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]3)[CH:13]=[C:14]3[C:23]=2[N:22]([CH:24]=1)[C:21]1[CH:20]=[C:19]([Br:25])[CH:18]=[CH:17][C:16]=1[S:15]3)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 748271-(2-Chloroethyl)piperidineHCID 18406569HCID 18406569, compound

Product 1

HCID 18406514HCID 18406514, compoundYield 60.2%

Procedure

According to Example 34, the compound (200 mg) produced in Example 70 was reacted with 1-(2-chloroethyl)piperidine (158 mg) to obtain the title compound (151 mg; 60%).

Sources & evidence

ORD record
ord-a09e2efb0b3d4ee7a9ccbabb65a19e1f
Source dataset
uspto-grants-2002_11
Patent number
US06476021B1

Reaction notes

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