Pyrimidine-5-carboxaldehyde → HCID 18406598, compound

HRID 1016329Notes

Reaction equation

HRID 1016329 reaction equation
[Br:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6]4=[C:7]([C:18](=[O:28])[C:19]([CH2:21][C:22]5[CH:23]=[N:24][CH:25]=C[CH:27]=5)=[CH:20][N:5]4[C:4]=2[CH:3]=1)[CH:8]=[C:9]([O:16][CH3:17])[CH:10]=3.[N:29]1C=C(C=O)C=NC=1>>[Br:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6]4=[C:7]([C:18](=[O:28])[C:19]([CH2:21][C:22]5[CH:23]=[N:24][CH:25]=[N:29][CH:27]=5)=[CH:20][N:5]4[C:4]=2[CH:3]=1)[CH:8]=[C:9]([O:16][CH3:17])[CH:10]=3

Participants

3

Reactant 2

HCID 2761034Pyrimidine-5-carboxaldehydeHCID 12021104HCID 12021104, compound

Product 1

HCID 18406598HCID 18406598, compoundYield 89.8%

Procedure

According to Example 1 <step 4>, the compound (2 g) produced in Example 36 <step 2> was reacted with pyrimidine-5-aldehyde (3.11 g) to obtain the title compound (1.8 g; 72%).

Sources & evidence

ORD record
ord-6f4c196355774dbba8a1f8de500566ac
Source dataset
uspto-grants-2002_11
Patent number
US06476021B1

Reaction notes

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