1-(2-Chloroethyl)piperidine → HCID 18406566, compound

HRID 1016332Notes

Reaction equation

HRID 1016332 reaction equation
[Br:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6]4=[C:7]([C:17](=[O:27])[C:18]([CH2:20][C:21]5[CH:22]=[N:23][CH:24]=[N:25][CH:26]=5)=[CH:19][N:5]4[C:4]=2[CH:3]=1)[CH:8]=[C:9]([OH:16])[CH:10]=3.Cl[CH2:29][CH2:30][N:31]1[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>>[Br:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6]4=[C:7]([C:17](=[O:27])[C:18]([CH2:20][C:21]5[CH:22]=[N:23][CH:24]=[N:25][CH:26]=5)=[CH:19][N:5]4[C:4]=2[CH:3]=1)[CH:8]=[C:9]([O:16][CH2:29][CH2:30][N:31]1[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1)[CH:10]=3

Participants

3

Reactant 2

HCID 748271-(2-Chloroethyl)piperidineHCID 18406553HCID 18406553, compound

Product 1

HCID 18406566HCID 18406566, compoundYield 51.5%

Procedure

According to Example 34, the compound (110 mg) produced in Example 76 was reacted with 1-(2-chloroethyl)piperidine (69 mg) to obtain the title compound (71 mg; 51%).

Sources & evidence

ORD record
ord-d5cd996b73a34a0ca61479ae49d37d73
Source dataset
uspto-grants-2002_11
Patent number
US06476021B1

Reaction notes

Loading…