HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromopropane → 2-Propoxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromopropane | HCID 7840 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Hydroxybenzonitrile | HCID 11907 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2-Propoxybenzonitrile | HCID 2760470 | — |
Reaction Steps
75 g (630 mmol) of 2-hydroxybenzonitrile, 174 g (1.26 mol) of potassium carbonate and 232.3 g (1.89 mol) of n-propyl bromide in 1 1 of acetone are refluxed overnight. The solid is filtered off, the solvent is removed under reduced pressure and the residue is distilled under reduced pressure. B.p.: 89° C. (0.7 mbar)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06476029B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-7431847ac0854cfb9aca2c364bc30b02 |
| Source note | uspto-grants-2002_11 |