Sulfuryl chloride → HCID 135552967, compound

HRID 1016353Notes

Reaction equation

[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[NH:16][C:15](=[O:17])[C:14]2=[C:18]([CH3:30])[N:19]=[C:20]([CH2:21][CH:22]([CH2:28][CH3:29])[CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[N:13]2[N:12]=1)[CH2:2][CH3:3].[S:31](Cl)([Cl:34])(=[O:33])=[O:32]>>[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([S:31]([Cl:34])(=[O:33])=[O:32])=[CH:7][C:6]=1[C:11]1[NH:16][C:15](=[O:17])[C:14]2=[C:18]([CH3:30])[N:19]=[C:20]([CH2:21][CH:22]([CH2:28][CH3:29])[CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[N:13]2[N:12]=1)[CH2:2][CH3:3]

Participants

Reactant 2

HCID 24648Sulfuryl chloride

HCID 135604921HCID 135604921, compound

Product 1

HCID 135552967HCID 135552967, compound

Procedure

The preparation is carried out analogously to the procedure of Example 27A using 1.4 g (3.41 mmol) of 2-(2-propoxyphenyl)-5-methyl-7-(2-ethylheptyl)-3H-imidazo[5,1-f]-[1,2,4]-triazin-4-one (Example 20A). This gives 1.4 g (80.6%) of sulphonyl chloride as a white foam which is directly reacted further.

Sources & evidence

ORD record: ord-5dc10445a84e4827a831e449c91222df
Source dataset: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06476029B1

Reaction notes

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