2-Fluorobenzhydrazide → HCID 178427628, compound

Participants

Reaction Steps

The product from step c) (10 g, 0.028 mol) was suspended in xylene (250 ml) with 2-fluorobenzoic hydrazide (4.7 g, 0.0231 mol) and heated under reflux for 3 h. After cooling, the reaction mixture was filtered and the solid produced was washed in the sinter funnel several times with dichloromethane then concentrated under vacuum to leave a solid (10.53 g). The product existed as a 1:1 mixture of 2 tautomers. 1H NMR (400 MHz, CDCl3) δ 2.37 (3H, s), 7.18-7.66 (12H, m), 8.06 (1H, s), 11.90 (0.5H, s), 13.78 (0.5H, s); MS (ES+) m/e 497 [MH]+.

Provenance & Evidence