Hydrochloric Acid → HCID 18406947, compound

Participants

Reaction Steps

To 2-[3,7-bis(2-Fluorophenyl)pyrazolo[1,5-d][1,2,4]triazin-2-yloxymethyl]-5,6-dihydro-8H-[1,2,4]triazolo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester (100 mg, 0.18 mmol) in ethyl acetate (3 ml) was added a saturated solution of hydrogen chloride in: ethyl acetate (2 ml), and the resultant mixture was stirred at room temperature for 5.5 h. 2-[3,7-Bis(2-fluorophenyl)pyrazolo[1,5-d][1,2,4]triazin-2-yloxymethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine hydrochloride was precipitated as a pale yellow solid, and was separated by filtration, washed thoroughly with ethyl acetate and dried (71 mg). Data for the title compound: 1H NMR (360 MHz, DMSO) δ 3.67 (2H, m), 4.37 (2H, t, J=5.8 Hz), 4.48 (2H, s), 5.39 (2H, s), 7.33-7.55 (5H, m), 7.69 (1H, td, J=7.6, 1.7 Hz), 7.77 (1H, m), 7.92 (1H, td, J=7.3, 1.7 Hz), 9.44 (1H, s), 10.07 (2H, br s); MS (ES+) m/e 461 [MH]+.

Provenance & Evidence