4-Benzylpiperidine → HCID 18407012, compound

HRID 1016434Notes

Reaction equation

HRID 1016434 reaction equation
[CH2:1]([CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:14][C:15]1([CH3:25])[O:22][C:21](=[O:23])[C:18]2([CH2:20][CH2:19]2)[C:17](=[O:24])[O:16]1>C1(C)C=CC=CC=1>[CH2:1]([CH:8]1[CH2:13][CH2:12][N:11]([CH2:20][CH2:19][CH:18]2[C:17](=[O:24])[O:16][C:15]([CH3:25])([CH3:14])[O:22][C:21]2=[O:23])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 317384-BenzylpiperidineHCID 797206,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione

Product 1

HCID 18407012HCID 18407012, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Following the procedure described in S. Danishefsky and R. K. Singh, J. American Chemical Society, 97:3239-3241(1975), a mixture of 0.5 g of 4-benzylpiperidine, 10 mL of toluene, and 0.5 g, of 6,6-dimethyl-5,7-dioxaspiro[2.5]octane 4,8-dione was stirred for 20 h, cooled, and, the white solid product collected by filtration and dried under vacuum. The yield of 5-[2-(4-benzyl-piperidin-1-yl)-ethyl]-2,2-dimethyl-[1,3]dioxane-4,6-dione was 0.94 g.

Workup

  1. temperaturecooled
  2. filtrationthe white solid product collected by filtration
  3. customdried under vacuum

Sources & evidence

ORD record
ord-02b5a51a745f4699858f2fe2e3d571c5
Source dataset
uspto-grants-2002_11
Patent number
US06476041B1

Reaction notes

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