Hydrochloric Acid → HCID 18406989, compound

Participants

Reaction Conditions

Reaction Steps

Slurry 4-(2,4-dimethoxyphenyl)-5-methyl-isoxazole (4.4 g) in 1.0 N NaOH (35 mL) and add 35 mL MeOH to dissolve. Heat at 60° C. under N2 for 1 hour, then cool to clear brown solution. Add 1.0 N HCl to acidify to pH 1, then filter the resulting white solid precipitate. Dissolve solid in EtOAc, dry over Na2SO4, filter and concentrate to red oil. Use without further purification. LCMS=220.2 (MH+); 218.2 (M−).

Provenance & Evidence