Acetic Acid → HCID 178476431, compound

HRID 1016459Notes

Reaction equation

HRID 1016459 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]1[C:13]([Cl:14])=[CH:12][C:11]([O:15][CH2:16][CH3:17])=[CH:10][C:9]=1[Cl:18].C(O[C:22](=[NH:24])[CH3:23])C.[C:25]([OH:28])(=[O:27])[CH3:26]>C(#N)C>[C:25]([OH:28])(=[O:27])[CH3:26].[NH:24]=[CH:22][CH2:23][NH:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]1[C:13]([Cl:14])=[CH:12][C:11]([O:15][CH2:16][CH3:17])=[CH:10][C:9]=1[Cl:18]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 65066Ethyl acetimidateHCID 178466677HCID 178466677, compound

Product 1

HCID 178476431HCID 178476431, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 5-amino-4-(4-ethoxy-2,6-dichlorophenyl)-3-methylpyrazole (4.8 g) in acetonitrile (50 mL) add ethylacetimidate (free base, 2.3 mL) followed by acetic acid (0.96 mL). Collect the precipitate that formed upon stirring overnight by filtration. Wash the solid with dry ether and dry to afford 5.02 g of (iminoethyl)[4-(4-ethoxy-2,6-dichlorophenyl)-3-methylpyrazol-5-yl]amine acetate salt as a white powder.

Workup

  1. customCollect the precipitate
  2. customthat formed
  3. washWash the solid with dry ether
  4. customdry

Sources & evidence

ORD record
ord-1124deb5f41a454f9a95ebf4f90b3828
Source dataset
uspto-grants-2002_11
Patent number
US06476038B1

Reaction notes

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