N-Iodosuccinimide → HCID 69545705, compound

Participants

Reaction Steps

To a 0° C. stirred solution of cyclopentyl-[2-(2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-ylamino)-ethyl]-carbamic acid tert-butyl ester (89 mg, 0.24 mmol) in chloroform (5 mL) was added N-iodosuccinimide (54 mg, 0.24 mmol). After stirring 30 minutes the reaction was extracted from saturated aqueous sodium thiosulfate with chloroform. The combined extracts were dried (Na2SO4), concentrated under reduced pressure to give the product as a slightly yellowed glass (102 mg, 85%): +APcI MS (M+1)+ 500; 1H NMR (CDCl3) δ: 5.82 (s, 1H), 4.25-4.10 (br s, 1H), 3.46 (s, 4H), 2.51 (s, 3H), 2.41 (s, 3H), 1.50 (s, 9H).

Provenance & Evidence