Hydrochloric Acid → N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-chloroacetamide

Participants

Reaction Steps

To a suspension of HCl salt of 2-amino-6(5H)-phenanthridinone (3.4 g, 0.014 mol) in ethyl acetate (200 mL) was added saturated solution of sodium bicarbonate (200 mL), followed by addition of chloroacetyl chloride (5.6 mL, 0.07 mol). The reaction mixture was stirred at room temperature for 2 days. The solid that separated out was filtered and washed thoroughly with cold water. It was then dried under vacuum to give N-(6-oxo-5, 6-dihydro-phenanthridin-2-yl)-chloroacetamide (3.35 gm, 85%).

Provenance & Evidence