HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Alfa-oxo-1H-pyrrolo-[2,3B]pyridine-3-acetic acid monopotassium salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 7-azaindole-3-glyoxylate | HCID 6028556 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | Alfa-oxo-1H-pyrrolo-[2,3B]pyridine-3-acetic acid monopotassium salt | HCID 23721194 | 90.4% |
Reaction Steps
Compound 2a (43 g, 0.21 mol) and K2CO3 (56.9 g, 0.41 mol) were dissolved in MeOH (200 ml) and H2O (200 ml). After 8 hours, product 3a precipitated out from the solution. Filtration afforded 43 g of compound 3a as a white solid in 90.4% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06476034B2 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-127d1864ea434f1a9a795bb9a1570d46 |
| Source note | uspto-grants-2002_11 |