HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → HCID 18407063, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-Chloroindole | HCID 87111 | — |
| Reactant | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 18407063 | HCID 18407063 | 72.2% |
Reaction Steps
A stirred solution of 6-chloroindole (455 mg, 3.0 mmol), t-butyl-4-oxo-1-piperidinecarboxylate (650 mg, 3.3 mmol), and pyrrolidine (0.62 mL, 7.4 mmol) in ethanol (10 mL) was heated at reflux for 16 hours. Solvent was evaporated and the residue was recrystallized from ethyl acetate and hexanes to afford a yellow solid (721 mg, 72%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06476051B2 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-f53188511b2344849a70d10c887ac787 |
| Source note | uspto-grants-2002_11 |