HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → HCID 18407064, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-Bromoindole | HCID 676493 | — |
| Reactant | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 18407064 | HCID 18407064 | 47% |
Reaction Steps
A stirred solution of 6-bromoindole (390 mg, 2.0 mmol), t-butyl-4-oxo-1-piperidinecarboxylate (438 mg, 2.2 mmol), and pyrrolidine (0.42 mL, 5.0 mmol) in ethanol (10 mL) was heated at reflux for 16 hours. Solvent was evaporated and the residue subjected to chromatography on silica gel with 20% ethyl acetate/hexanes to afford a yellow solid (354 mg, 47%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06476051B2 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-62055ef6e4a94bafa5220b3371b92ef7 |
| Source note | uspto-grants-2002_11 |