HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → HCID 18407062, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| Reactant | 7-Bromoindole | HCID 2757020 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 18407062 | HCID 18407062 | 29% |
Reaction Steps
A stirred solution of 7-bromoindole (390 mg, 2.0 mmol), t-butyl-4-oxo-1-piperidinecarboxylate (438 mg, 2.2 mmol), and pyrrolidine (0.42 mL, 5.0 mmol) in ethanol (10 mL) was heated at reflux for 16 hours. Solvent was evaporated and the residue subjected to chromatography on silica gel with 20% ethyl acetate/hexanes to afford a yellow solid (215 mg, 29%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06476051B2 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-e80f25d69d924ac186cde7f6ca2b1c78 |
| Source note | uspto-grants-2002_11 |