HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 2-Bromo-5-chloro-2,3-dihydro-1H-inden-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 5-Chloro-1-indanone | HCID 142599 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Bromo-5-chloro-2,3-dihydro-1H-inden-1-one | HCID 11334069 | — |
Reaction Steps
Bromination of 5-chloro-1-indanone in glacial acetic acid with bromine and with addition of catalytic amounts of 48% strength HBr solution in water affords 2-bromo-5-chloro-1-indanone with a melting point of 94-96° C. A little of the corresponding dibromo compound is obtained as byproduct.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06476059B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-bf01d3f1a60048418d7e14615a57fc98 |
| Source note | uspto-grants-2002_11 |