HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 4-Amino-1-Boc-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1,1-Dimethylethyl 4-azido-1-piperidinecarboxylate | HCID 11458794 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 4-Amino-1-Boc-piperidine | HCID 1268291 | 97.6% |
Reaction Steps
A solution of 4.05 g (17.9 mmol) of 4-azido-1-(tert-butoxycarbonyl)piperidine from Step A in 50 mL of methanol was hydrogenated with 350 mg of 10% Pd/C under a hydrogen balloon for 16 h when the reaction was complete by TLC (10% ethyl acetate in hexane). The catalyst was filtered off and the volatiles removed in vacuo to give 3.5 g of title compound which was used directly in subsequent reactions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06476054B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-c853e22dccb544d5ae7e2b123394a313 |
| Source note | uspto-grants-2002_11 |