Aniline → N-[(S)-2-(3,4-Dichlorophenyl)-4-(phenylamino)butyl]-N-methyl-2-methoxy-3-cyano-1-naphthamide

Participants

Reaction Steps

N-[(S)-2-(3,4-Dichlorophenyl)-4-oxobutyl]-N-methyl-2-methoxy-3-cyano-1-naphthamide was reacted with aniline under standard reductive amination conditions to give the title compound which was converted to the citrate salt. 1H NMR(300 MHz, DMSO-d6) δ8.64-8.61 (m), 8.07-7.98 (m), 7.79-7.55 (m), 7.51-7.47 (m), 7.37-7.32 (t), 7.08-7.00 (m), 6.53-6.49 (m), 6.31-6.28 (d), 4.60-4.50 (t), 4.07-3.96 (m), 3.92 (s), 3.90-3.78 (m), 3.86 (s), 3.45-3.11 (m), 3.00-2.88 (m), 2.79 (s), 2.73 (s), 2.68 (s), 2.56-2.44 (m), 2.03-1.88 (m); MS APCI, m/z=532 (M+).

Provenance & Evidence