HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Sibutramine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sibutramine | HCID 5210 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | Sibutramine Hydrochloride | HCID 64764 | — |
Reaction Steps
Sibutramine free base (2.25 g) was dissolved in MTBE (20 mL) and that solution was added to 20 mL 1M HCl in diethyl ether. The reaction mixture was stirred for 30 minutes, and the solid was collected by filtration to give 1.73 g after drying. The product was characterized by 1H NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06476078B2 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-97b75608e7f4454596957661fde311bb |
| Source note | uspto-grants-2002_11 |