HCID 18407038, compound → HCID 18407034, compound

HRID 1016637Notes

Reaction equation

HRID 1016637 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([NH2:8])=[C:4](I)[CH:3]=1.[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]#[C:18][CH2:19][CH2:20][C:21]([O:23][CH3:24])=[O:22])=[CH:13][CH:12]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:18]([CH2:19][CH2:20][C:21]([O:23][CH3:24])=[O:22])=[C:17]([C:14]3[CH:15]=[CH:16][C:11]([Cl:10])=[CH:12][CH:13]=3)[NH:8][C:5]2=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 18407038HCID 18407038, compoundHCID 184070406-Chloro-4-iodopyridin-3-amine

Product 1

HCID 18407034HCID 18407034, compound

Procedure

Prepared from 6-chloro-4-iodo-3-pyridinamine (Description 8) and methyl 5-(4-chlorophenyl)-4-pentynoate (Description 2) according to the method of Description 4. 1H NMR (360 MHz, CDCl3) δ 8.56 (1H, br s), 8.50 (1H, s), 7.50 (5H, m), 3.63 (3H, s), 3.15 (2H, t, J 7.9 Hz), and 2.62 (2H, t, J 7.9 Hz). m/z (ES+) 349, 351 (M+1).

Sources & evidence

ORD record
ord-0ff9e5b5554849fa912f42dc0f3ad36c
Source dataset
uspto-grants-2002_11
Patent number
US06476045B2

Reaction notes

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