HCID 18407038, compound → HCID 18407049, compound

HRID 1016638Notes

Reaction equation

HRID 1016638 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](I)[C:5]([NH2:9])=[CH:4][CH:3]=1.[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]#[C:18][CH2:19][CH2:20][C:21]([O:23][CH3:24])=[O:22])=[CH:13][CH:12]=1>>[Cl:1][C:2]1[N:7]=[C:6]2[C:18]([CH2:19][CH2:20][C:21]([O:23][CH3:24])=[O:22])=[C:17]([C:14]3[CH:13]=[CH:12][C:11]([Cl:10])=[CH:16][CH:15]=3)[NH:9][C:5]2=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 18407038HCID 18407038, compoundHCID 184070436-Chloro-2-iodopyridin-3-amine

Product 1

HCID 18407049HCID 18407049, compound

Procedure

Prepared from 6-chloro-2-iodo-3-pyridinamine (Description 14) and methyl 5-(4-chlorophenyl)-4-pentynoate (Description 2) according to the method of Description 4. 1H NMR (500 MHz, CDCl3) δ 8.20 (1H, br s), 7.56 (1H, d, J 8.4 Hz), 7.52 (2H, d, J 8.5 Hz), 7.47 (2H, d, J 8.5 Hz), 7.11 (1H, d, J 8.4 Hz), 3.61 (3H, s), 3.21 (2H, t, J 7.8 Hz), and 2.85 (2H, t, J 7.8 Hz).

Sources & evidence

ORD record
ord-9a40308d9acc47e782b9e9505ea1a2e5
Source dataset
uspto-grants-2002_11
Patent number
US06476045B2

Reaction notes

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