Isopropanol → HCID 9886235, compound

Participants

Reaction Steps

Prepared from 2-nitrophenylacetic acid [solvent for purification- CH2Cl2:CH3OH: 28%NH4OH (98:2:2)]: yield 21% as a white solid (2-propanol); mp 267-269° C. (d); 1H NMR((200 MHz, CDCl3) δ1.00-1.44 (m, 2H), 1.60-2.35 (m, 8H), 2.85 (m, 1H), 3.15 (s, 3H), 3.18-3.35 (m, 4H), 3.40 (m, 1H), 3.85 (m, 1H), 4.33 (dd, J=10.0 Hz, 2H), 4.64 (m, 1H), 7.35 (m, 1H), 7.56 (m, 2H), 8.05 (d, J=7.8 Hz, 1H), 11.02 (bs, 1H). Anal. Calcd for C19H27N3O3.HCl: C, 59.75; H, 7.39; Cl, 9.28; N, 11.00. Found: C, 59.98; H, 7.38; 8.96; N, 10.85.

Provenance & Evidence