HCID 22894817, compound → HCID 15875321, compound

Participants

Reaction Steps

1.0 g (3.6 mmol) diacetate 13 is dissolved in 17 ml EtOH and hydrogenated over PtO2. The catalyst is removed by filtration over Celite and the solvent is evaporated. Flash chromatography of the crude product gave 0.83 g (82% by weight) of compound 14 in the form of a yellowish oil having the following: 1H NMR (CDCl3) values: 0.81 (d, J=7.0 CH3); 0.98 (d, J=7.0, CH3); 1.98-2.15 (m, 1H, CH); 2.08 (s, CH3); 2.30 (s, CH3); 3.82 (s, OCH3); 5.46 (d, J=7.0, CH); 6.84-7.02 (m, 3 aromatic H). MS: 280 (8, [M+]), 238 (38), 195 (56), 153 (100), 43 (68).

Provenance & Evidence