Benzaldehyde → (+)-Benzylphenethylamine

Participants

Reaction Steps

412 kg of methanol and 375.7 kg of (R)-1-phenylethylamine (ee=97.1%) are initially taken and 329 kg of benzaldehyde are added dropwise at 24° C. in the course of 120 minutes. Stirring is effected for 6 hours at 24° C., the completeness of the iminization is checked by GC, 6 kg of Pd/C (5% by weight) are added and the crude mixture is hydrogenated with hydrogen for 24 hours at atmospheric pressure. The sample is taken and the composition is investigated by GC analysis.

Provenance & Evidence