2,2'-Bipyridine → HCID 178445812, compound

Participants

Reaction Steps

RuClCp* (cod) (3.8 mg, 0.01 mmol), KOH (0.04 mmol), 2,2′-bipyridyl (3.1 mg, 0.02 mmol) and 4-t-butylcyclohexanone (385.63 mg, 2.5 mmol) were dissolved into 10 ml of 2-propanol, and deaerated by argon substitution, after which the total amount of the resulting mixture was transferred into a 100-milliliter metallic autoclave. Then, the reaction was started at room temperature (28° C.) while conducting argon substitution. After the reaction solution was stirred for 18 hours, the reaction produces, cis-4-t-butylcyclohexanol (yield 8.6%) and trans-4-t-butylcyclohexanol (yield 21.1%), were identified and quantitatively determined by TLC monitor (silica gel: n-hexane/ethyl acetate=4/1) and gas chromatography of the reaction solution. Here, 35.0% of the raw material, 4-t-butylcyclohexanone, was recovered.

Provenance & Evidence