Benzyl isocyanide → HCID 178501559, compound

HRID 1016798Notes

Reaction equation

HRID 1016798 reaction equation
[Cl:1][C:2]1[CH:16]=[C:15]([Cl:17])[CH:14]=[C:13]([CH:18]=O)[C:3]=1[O:4][CH2:5][C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7].[NH2:20][C:21]1[CH:30]=[CH:29][C:24]([C:25]([NH:27][OH:28])=[NH:26])=[CH:23][CH:22]=1.C([N+]#[C-])C1C=CC=CC=1>>[C:9]([O:8][C:6]([CH2:5][O:4][C:3]1[C:2]([Cl:1])=[CH:16][C:15]([Cl:17])=[CH:14][C:13]=1[CH:18]([NH:20][C:21]1[CH:30]=[CH:29][C:24]([C:25](=[NH:26])[NH:27][OH:28])=[CH:23][CH:22]=1)[C:6]([O:8][CH3:9])=[O:7])=[O:7])([CH3:10])([CH3:11])[CH3:12]

Participants

4

Reactant 3

HCID 82558Benzyl isocyanideHCID 183536852-Tert-butoxycarbonylmethoxy-3,5-dichlorobenzaldehydeHCID 178513341HCID 178513341, compound

Product 1

HCID 178501559HCID 178501559, compound

Procedure

In analogy to Example 1.1., tert-butyl (2,4-dichloro-6-formyl-phenoxy)-acetate was reacted with 4-amino-N-hydroxybenzamidine and benzyl isonitrile. There was obtained methyl (RS)-(2-tert-butoxycarbonylmethoxy-3,5-dichloro-phenyl)-[4-(N-hydroxycarbamimidoyl)-phenylamino]-acetate; MS (ISP) m/z 498.2 (M+H)+, 520.2 (M+Na)+.

Sources & evidence

ORD record
ord-1526d67d2aaf4df29205efbfbed73a31
Source dataset
uspto-grants-2002_11
Patent number
US06476264B2

Reaction notes

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