2-(4-Fluorophenyl)acetic acid → 2-[(4-Fluorophenyl)acetamido]butyric acid isobutyl ester

HRID 1016839Notes

Reaction equation

HRID 1016839 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 98372-(4-Fluorophenyl)acetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 541443992-[(4-Fluorophenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure I′ above and using 4-fluorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-daf7d87fcb5a41a48b72caea2459cb40
Source dataset
uspto-grants-2002_11
Patent number
US06476263B1

Reaction notes

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