3-Nitrophenylacetic acid → N-[(3-nitrophenyl)acetyl]methionine Ethyl Ester

HRID 1016858Notes

Reaction equation

HRID 1016858 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]([OH:13])=O)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].Cl.[CH2:15]([O:17][C:18](=[O:25])[C@H:19]([CH2:21][CH2:22][S:23][CH3:24])[NH2:20])[CH3:16]>>[CH2:15]([O:17][C:18](=[O:25])[C@H:19]([CH2:21][CH2:22][S:23][CH3:24])[NH:20][C:11](=[O:13])[CH2:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[CH3:16]

Participants

3

Reactant 2

HCID 158763-Nitrophenylacetic acidHCID 3083785Ethyl L-methionate hydrochloride

Product 1

HCID 53910855N-[(3-nitrophenyl)acetyl]methionine Ethyl Ester

Procedure

Following General Procedure G′ above and using 3-nitrophenylacetic acid (Aldrich) and methionine ethyl ester hydrochloride (Aldrich), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by recrystallization from butyl chloride.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. customwas by recrystallization from butyl chloride

Sources & evidence

ORD record
ord-ad8fe2d63cf54459b2842941059591b0
Source dataset
uspto-grants-2002_11
Patent number
US06476263B1

Reaction notes

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