HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate → Methyl 2-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-1,2,3,4tetrahydroisoquinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate | HCID 4685119 | — |
| Reactant | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | Methyl 2-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-1,2,3,4tetrahydroisoquinoline-3-carboxylate | HCID 10158832 | — |
Reaction Steps
Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate (Aldrich), the title compound was prepared as a solid (mp=37-40° C.). The reaction was monitored by tlc (Rf=0.64 in 10% MeOH/DCM).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06476263B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-1fc070bede5b4e00a3436e7863e8fe7d |
| Source note | uspto-grants-2002_11 |