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HRID1016903

反应详情

EQUATION

反应方程式

HRID 1016903 的结构方程式

REACTANTS

反应物

2
结构：C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O
HCID12135350

N-[(3,5-difluorophenyl)acetyl]alanine

C11H11F2NO3

结构：CC(C)C[C@H](N)C(=O)OC(C)(C)C.Cl
HCID12451443

tert-Butyl leucinate--hydrogen chloride (1/1)

C10H22ClNO2

PRODUCTS

生成物

1
结构：CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)Cc1cc(F)cc(F)c1)C(=O)OC(C)(C)C
HCID22894891

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO.ClCCl
溶剂HCID21226129

未命名化合物

PROCEDURE

实验过程

Following General Procedure B and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and L-leucine tert-butyl ester hydrochloride (Bachem), the title compound was prepared as a solid (mp=128° C.). The reaction was monitored by tlc (Rf=0.85 in 5% MeOH/methylene chloride) and the product was purified by flash column chromatography using 5% MeOH/methylene chloride as the eluent.

WORKUP

后处理

  1. customthe product was purified by flash column chromatography