HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexaneacetic acid → N-[N-(Cyclohexylacetyl)-L-alaninyl]-L-phenylalanine Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexaneacetic acid | HCID 21363 | — |
| Reactant | Methyl L-phenylalaninate hydrochloride | HCID 75736 | — |
| Reactant | Tert-butoxycarbonylalanine | HCID 85082 | — |
| Reactant | Alanylphenylalanine methyl ester | HCID 12988705 | — |
| Product | N-[N-(Cyclohexylacetyl)-L-alaninyl]-L-phenylalanine Methyl Ester | HCID 9799725 | — |
Reaction Steps
Following General Procedure U and using cyclohexylacetic acid (Aldrich) and N-(L-alaninyl)-L-phenylalanine methyl ester (prepared by coupling N-BOC-L-alanine (Bachem) with L-phenylalanine methyl ester hydrochloride (Bachem) using General Procedure U, followed by removal of the BOC-group using General Procedure Y), the title compound was prepared as a solid (mp=156-158° C.). The reaction was monitored by tlc (Rf=0.25 in 1:1 EtOAc/hexanes).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06476263B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-d55d9dc7cc9e4b6383ba72720b76a8f0 |
| Source note | uspto-grants-2002_11 |