HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl L-threoninate hydrochloride → N-[N-(3-Nitrophenylacetyl)-L-alaninyl]-L-threonine Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl L-threoninate hydrochloride | HCID 2734893 | — |
| Reactant | N-(3-Nitrophenylacetyl)-L-alanine | HCID 53788870 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | N-[N-(3-Nitrophenylacetyl)-L-alaninyl]-L-threonine Methyl Ester | HCID 22895021 | — |
Reaction Steps
Following General Procedure C and using N-(3-nitrophenylacetyl)-L-alanine (from Example D11 above) and L-threonine methyl ester hydrochloride (Aldrich), the title compound was prepared as a solid. The reaction was monitored by tlc (Rf=0.1 in 95:5 CHCl3/MeOH) and the product was purified by silica gel chromatography using 95:5 CHCl3/MeOH as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06476263B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-75e15b1de76f4c54a289c7274f3bb509 |
| Source note | uspto-grants-2002_11 |