(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → HCID 22894872, compound

HRID 1016960Notes

Reaction equation

HRID 1016960 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([OH:17])=O)[CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[NH2:18][CH:19]([C:24]1[S:31][C:27]2[S:28][CH:29]=[CH:30][C:26]=2[CH:25]=1)[C:20]([O:22][CH3:23])=[O:21]>>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([NH:18][CH:19]([C:24]2[S:31][C:27]3[S:28][CH:29]=[CH:30][C:26]=3[CH:25]=2)[C:20]([O:22][CH3:23])=[O:21])=[O:17])[CH3:14])=[O:11])[CH:3]=[C:2]([F:1])[CH:7]=1

Participants

3

Reactant 2

HCID 12135350(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acidHCID 22492314HCID 22492314, compound

Product 1

HCID 22894872HCID 22894872, compound

Procedure

Following General Procedure C and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and methyl 2-amino-2-(thieno[2,3-b]thiophen-2-yl)acetate (from Example D4 above), the title compound was prepared as a solid. The product was purified by titruation from Et2O/hexanes.

Workup

  1. customThe product was purified by titruation from Et2O/hexanes

Sources & evidence

ORD record
ord-d7415de4ab76450e80f252e31b2eca23
Source dataset
uspto-grants-2002_11
Patent number
US06476263B1

Reaction notes

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