3-(Benzyl(3-fluorophenyl)amino)-1,1,1-trifluoropropan-2-ol → 3-[(3-Fluorophenyl)amino]-1,1,1-trifluoro-2-propanol

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Reaction Steps

EX-662A) 3-[(3-fluorophenyl)[phenylmethyl]amino]-1,1,1-trifluoro-2-propanol (2.56 g, 8.2 mmol) was dissolved in methanol (30 mL) and hydrogenated over 5% palladium on charcoal for 3 h. The mixture was filtered through celite, and the solvent was removed in vacuo to give 1.8 g (98%) of the desired 3-[(3-fluorophenyl)amino]-1,1,1-trifluoro-2-propanol product as an oil, 99% pure by HPLC analysis. MS m/z=224 [M+H]+.

Provenance & Evidence