HuagongsheHuagongshe Chemistry Print Report · For research reference only
Maleic Anhydride → 6-Maleimidohexanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Maleic Anhydride | HCID 7923 | — |
| Reactant | 6-Azaniumylhexanoate | HCID 517030 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-Maleimidohexanoic acid | HCID 573683 | — |
Reaction Steps
The symmetrical anhydride of 6-Maleimidocaproic acid (Compound 24, FIG. 5) was prepared by the reaction of maleic anhydride and e-Amino-n-caproic acid in the presence of acetic acid to give 6-Maleimidocaproic acid (Compound 23) which was then converted to Compound 24 using dicyclohexyl carbodiimide (DCCl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06479265B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-1ffaa50c202c4ec8a2cb0f52434e6a2b |
| Source note | uspto-grants-2002_11 |